TGF-β in jaw tumor fluids induces RANKL expression in stromal fibroblasts
نویسندگان
چکیده
منابع مشابه
TGF-β in jaw tumor fluids induces RANKL expression in stromal fibroblasts
Odontogenic tumors and cysts, arising in the jawbones, grow by resorption and destruction of the jawbones. However, mechanisms underlying bone resorption by odontogenic tumors/cysts remain unclear. Odontogenic tumors/cysts comprise odontogenic epithelial cells and stromal fibroblasts, which originate from the developing tooth germ. It has been demonstrated that odontogenic epithelial cells of t...
متن کاملTGF-β Induces RANKL Expression in Vascular Endothelial Cells Derived from Bone*
Footnotes *This study was supported by a special grant for Advanced Research on Cancer from the Ministry of Education, Culture, Sports, Science and Technology, Japan. ¶To whom correspondence should be addressed. Tel: +81-3-5841-7861, Fax: +81-3-5841-8487, E-mail: [email protected] The abbreviations used in this paper; BDECs, bone marrow-derived endothelial cells; CRE, cyclic AMP respons...
متن کاملExpression of TGF-β3 in Isolated Fibroblasts from Foreskin
Background: The multifunctional transforming growth factor beta (TGF-β) is a glycoprotein that exists in three isoforms. TGF-β3 expression increases in fetal wound healing and reduces fibronectin and collagen I and III deposition, and also improves the architecture of the neodermis which is a combination of blood vessels and connective tissue during wound healing. Fibroblasts are key ...
متن کاملStromal TGF-β signaling induces AR activation in prostate cancer
AR signaling is essential for the growth and survival of prostate cancer (PCa), including most of the lethal castration-resistant PCa (CRPC). We previously reported that TGF-β signaling in prostate stroma promotes prostate tumor angiogenesis and growth. By using a PCa/stroma co-culture model, here we show that stromal TGF-β signaling induces comprehensive morphology changes of PCa LNCaP cells. ...
متن کاملDesmin expression by a gastrointestinal stromal tumor in a dog
This report describes the histological and immunohistochemical features of a small intestinal tumor that resembled a human gastrointestinal stromal tumor (GISTs) in a seven-year-old male cross-breed dog. This was unique because of the expression of desmin by the tumor. Grossly, the white-gray tumor measured 8.0 × 4.0 × 6.5 cm and was 760 gram in weight. It was cystic and enveloped the jejunum. ...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: International Journal of Oncology
سال: 2016
ISSN: 1019-6439,1791-2423
DOI: 10.3892/ijo.2016.3548